At Department of Composites and Carbon Materials, we’ve been applying electrospinning for preparing submicron and nanofibers based on natural or synthetic polymers, mainly for preparing collagen or collagen fibers incorporating various nanoparticles such as bioapatite or calcium phosphates. The combination of electrospinning and electroblowing, which 4SPIN (Contipro, a.s.) allows, can help us to preserve the typical and advantageous unique biological properties of collagen and imitate the major part of extracellular matrix. The potential application of our present research would be osteo-inductive resorbable biomimetic layer allowing the controlled elution of antibiotics to be used as a bone/implant bioactive interface articularly in the case of prosthetic joint infections. Further potential applications are scaffolds for various cell types, local drug carriers or wound dressing.